Publications

Introduction to optical tweezers: background, system designs, and commercial solutions

Malinowska, A. M., van Mameren, J., Peterman, E. J. G., Wuite, G. J. L. & Heller, I.
Book Chapter in Methods in Molecular Biology, Single Molecule Analysis, 2694 3-28 (2024)

Regulation of T7 gp2.5 binding dynamics by its C-terminal tail, template conformation and sequence

Xu, L., Cabanas-Danés, J., Halma, M. T. J., Heller, I., Stratmann, S. A., van Oijen, A. M., Lee, S. J., Peterman, E. J. G. & Wuite, G. J. L.
Nucleic acids research, 51 13, 6540-6553 (2023)

Nonlinear mechanics of human mitotic chromosomes

Meijering AEC, Sarlos K, Nielsen CF, Witt H, Harju J, Kerklingh E, Haasnoot GH, Bizard AH, Heller I, Broedersz CP, Liu Y, Peterman EJG, Hickson ID, Wuite GJL
Nature, 605 545 (2022)

Extreme mechanics of colloidal polymers under compression: Buckling, creep, and break-up

Stuij SG, Biebricher AS, Gong Z, Sacanna S, Peterman EJG, Heller I, Schall P
Phys. Rev. Materials, 6 (3) 035603 (2022)

Implementation of 3D Multi-Color Fluorescence Microscopy in a Quadruple Trap Optical Tweezers System

Meijering, A. E. C., Bakx, J. A. M., Man, T., Heller, I., Wuite, G. J. L. & Peterman, E. J. G.
Book Chapter in Methods in Molecular Biology, Optical Tweezers: Methods and Protocols, 2478 75-100 (2022)

One-Dimensional STED Microscopy in Optical Tweezers

Man, T., Geldhof, J. J., Peterman, E. J. G., Wuite, G. J. L. & Heller, I.
Book Chapter in Methods in Molecular Biology, Optical Tweezers: Methods and Protocols, 2478 101-122 (2022)

Temperature Quantification and Temperature Control in Optical Tweezers

Geldhof, J. J., Malinowska, A. M., Wuite, G. J. L., Peterman, E. J. G. & Heller, I.
Book Chapter in Methods in Molecular Biology, Optical Tweezers: Methods and Protocols, 2478 123-140 (2022)

Direct imaging of intraflagellar-transport turnarounds reveals that motors detach, diffuse, and reattach to opposite-direction trains

Zhang Z, Danné N, Meddens B, Heller I, Peterman EJG
Proceedings of the National Academy of Sciences of the U.S.A., 118 (45) e2115089118 (2021)

Elucidating the Role of Topological Constraint on the Structure of Overstretched DNA Using Fluorescence Polarization Microscopy

Backer AS, King GA, Biebricher AS, Shepherd JW, Noy A, Leake MC, Heller I, Wuite GJL, Peterman EJG
J. Phys. Chem. B, 125 (3) 8351-8361 (2021)

Imaging unlabeled proteins on DNA with super-resolution

Meijering AEC, Biebricher AS, Sitters G, Brouwer I, Peterman EJG, Wuite GJL, Heller I
Nucleic Acids Research, 48 e34 (2020)

Single-molecule polarization microscopy of DNA intercalators sheds light on the structure of S-DNA

Backer AS, Biebricher AS, King GA, Wuite GJL*, Heller I*, Peterman EJG*
Science Advances, 5 eaav1083 (2019)

Quantifying local molecular tension using intercalated DNA fluorescence

King GA*, Biebricher AS*, Heller I*, Peterman EJG, Wuite GJL
Nano Letters, 18 2274 (2018)

Hyperstretching DNA

Schakenraad K, Biebricher AS, Sebregts M, ten Bensel B, Peterman EJG, Wuite GJL, Heller I*, Storm C*, van der Schoot P*
Nature communications, 8 2197 (2017)

Versatile Quadruple-Trap Optical Tweezers for Dual DNA Experiments

Heller I, Laurens N, Vorselen D, Broekmans OD, Biebricher AS, King GA, Brouwer I, Wuite GJL, Peterman EJG
Book Chapter in Methods in Molecular Biology, Optical Tweezers, 1468 257-272 (2018)

Probing DNA–DNA Interactions with a Combination of Quadruple-Trap Optical Tweezers and Microfluidics

Brouwer I, King GA, Heller I, Biebricher AS, Peterman EJG, Wuite GJL
Book Chapter in Methods in Molecular Biology, Optical Tweezers, 1468 275-293 (2018)

Introduction to optical tweezers: background, system designs, and commercial solutions

Mameren J, Wuite GJL, Heller I
Book Chapter in Methods in Molecular Biology, Single Molecule Analysis, 1665 3-23 (2018)

How to switch the motor on: RNA polymerase initiation steps at the single-molecule level

Marchetti M, Malinowska A, Heller I*, Wuite GJL*
Protein Science, 26 1303 (2017)

Single-molecule observation of DNA compaction by meiotic protein SYCP3

Syrjanen, JL*, Heller I*, Candelli A, Davies OR, Peterman EJG, Wuite GJL, Pellegrini, L
eLife, 6 e22582 (2017)

Sliding sleeves of XRCC4–XLF bridge DNA and connect fragments of broken DNA

Brouwer I*, Sitters, G*, Candelli A, Heerema SJ, Heller I, de Melo AJ, Zhang H, Normanno D, Modesti M, Peterman EJG, Wuite GJL
Nature, 535 566 (2016)

image: J.Langeveld

The impact of DNA intercalators on DNA and DNA-processing enzymes elucidated through force-dependent binding kinetics

Biebricher AS*, Heller I*, Roijmans RFH, Hoekstra TP, Peterman EJG, Wuite GJL
Nature communications, 6 7304 (2015)

Visualization and quantification of nascent RAD51 filament formation at single-monomer resolution

Candelli A, Holthausen JT, Depken M, Brouwer I, Franker MAM, Marchetti M, Heller I, Bernard S, Garcin EB, Modesti M, Wyman C, Wuite GJL, Peterman EJG
Proceedings of the National Academy of Sciences of the U.S.A., 111 15090 (2014)

Optical tweezers analysis of DNA-protein complexes

Heller I, Hoekstra TP, King GA, Peterman EJG, Wuite GJL
Chemical Reviews, 114 3087 (2014)

Mobility analysis of super-resolved proteins on optically stretched DNA: comparing imaging techniques and parameters

Heller I*, Sitters G*, Biebricher AS, Broekmans OD, Wuite GJL, Peterman EJG
ChemPhysChem, 15 727 (2014)

STED nanoscopy combined with optical tweezers reveals protein dynamics on densely covered DNA

Heller I, Sitters G, Broekmans OD, Farge G, Menges C, Wende W, Hell SW, Peterman EJG, Wuite GJL
Nature Methods, 10 910 (2013)

Alba shapes the archaeal genome using a delicate balance of bridging and stiffening the DNA

Laurens N, Driessen RPC, Heller I, Vorselen D, Noom MC, Hol FJH, White MF, Dame RT, Wuite GJL
Nature Communications, 3 1328 (2012)

Influence of electrolyte composition on liquid-gated carbon-nanotube and graphene transistors

Heller I, Chatoor S, Männik J, Zevenbergen MAG, Dekker C, Lemay SG
J. Am. Chem. Soc., 132 17149 (2010)

Monitoring in vivo absorption of a drug-eluting bioabsorbable stent with intravascular ultrasound-derived parameters: a feasibility study

Bruining N, de Winter S, Roelandt JRTC, Regar E, Heller I, van Domburg RT, Hamers R, Onuma Y, Dudek D, Webster MWI, Thuesen L, Ormiston JA, Cheong WF, Miquel-Hebert K, Veldhof S, Serruys PW
JACC-Cardiovascular Interventions 3 449 (2010)

Charge noise in graphene transistors

Heller I, Chatoor S, Männik J, Zevenbergen MAG, Oostinga JB, Morpurgo AF, Dekker C, Lemay SG
Nano Letters, 10 1563 (2010)

Probing macrophage activity with carbon nanotube sensors

Heller I, Smaal WTT, Lemay SG, Dekker C
Small, 5 2528 (2009)

Comparing the weak and strong gate-coupling regimes for nanotube and graphene transistors

Heller I, Chatoor S, Männik J, Zevenbergen MAG, Dekker C, Lemay SG
Physica Status Solidi – RRL, 3 190 (2009)

Optimizing the signal-to-noise ratio for biosensing with carbon nanotube transistors

Heller I, Männik J, Lemay SG, Dekker C
Nano Letters, 9 377 (2009)

Coronary calcium significantly affects quantitative analysis of coronary ultrasound: importance for atherosclerosis progression/regression studies

Bruining N, de Winter S, Roelandt JRTC, Rodriguez-Granillo GA, Heller I, van Domburg RT, Hamers R, de Feijter PJ
Coronary Artery Disease, 20 409 (2009)

Charge noise in liquid-gated single-wall carbon nanotube transistors

Männik J, Heller I, Janssens AM, Lemay SG, Dekker C
Nano Letters, 8 685 (2008)

Identifying the mechanism of biosensing with carbon nanotube transistors

Heller I, Janssens AM, Männik J, Minot ED, Lemay SG, Dekker C
Nano Letters, 8 591 (2008)

Polymyxin-coated Au and carbon nanotube electrodes for stable [NiFe]-hydrogenase film voltammetry

Hoeben FJM, Heller I, Albracht SPJ, Dekker C, Lemay SG
Langmuir, 24 5925 (2008)

Simultaneous electrical transport and scanning tunneling spectroscopy of carbon nanotubes

LeRoy BJ, Heller I, Pahilwani VK, Dekker C, Lemay SG
Nano Letters, 7 2937 (2007)

Three-dimensional and quantitative analysis of atherosclerotic plaque composition by automated differential echogenicity

Bruining N, Verheye S, Knaapen M, Somers P, Roelandt JRTC, Regar E, Heller I, de Winter S, Ligthart J, Van Langenhove G, de Feijter PJ, Serruys PW, Hamers R
Catheterization and Cardiovascular Interventions, 70 968 (2007)

Carbon nanotube biosensors: the critical role of the reference electrode

Minot ED, Janssens AM, Heller I, Heering HA, Dekker C, Lemay SG
Applied Physics Letters 91 093507/1- (2007)

Electrochemistry at single-walled carbon nanotubes: the role of band structure and quantum capacitance

Heller I, Kong J, Williams KA, Dekker C, Lemay SG
J. Am. Chem. Soc., 128 7353 (2006)

Individual single-walled carbon nanotubes as nanoelectrodes for electrochemistry

Heller I, Kong J, Heering HA, Williams KA, Lemay SG, Dekker C
Nano Letters, 5 137 (2005)