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- Professor in Physics of Living Systems Section
Gijs Wuite focuses his research exploring DNA-proteins interactions and biophysical/biomechanical properties of viral capsids & cells. The aim is to work with increasingly more complex assemblies of proteins in order to investigate the emergent properties from these systems. This approach bridges experimental systems biology and single-molecule manipulation techniques. We use a variety of techniques such as optical tweezers, AFM and single-molecule fluorescence as well as combinations of these techniques. The data obtained are related to biochemical studies and used for theoretical modeling.
Wuite teaches students in Physics, Medical Natural Sciences, and the Amsterdam University College at the bachelor and master level. He is involved in the development of Amsterdam Faculty of Sciences.. Moreover, he is board member of the Young Academy (KNAW).
G. Farge, N. Laurens, O.D. Broekmans, S.M.J.L. van den Wildenberg, L.C.M. Dekker, M. Gaspari, C.M. Gustafsson, E.J.G. Peterman, M. Falkenberg, G.J.L. Wuite. Protein sliding and DNA denaturation are essential for DNA organization by human mitochondrial transcription factor A. Nature Communications 3:1013 (2012)
Gross, P., Laurens, N., Oddershede, L. B., Bockelmann, U., Peterman, E. J. G., and Wuite, G. J. L. Quantifying how DNA stretches, melts and changes twist under tension, Nature Physics 7, 731-736, (2011).
van Mameren, J., Modesti, M., Kanaar, R., Wyman, C., Peterman, E. J. G. & Wuite, G. J. L. Counting RAD51 proteins disassembling from nucleoprotein filaments under tension. Nature 457, 745-748, (2009).
van Mameren, J., Gross, P., Farge, G., Hooijman, P., Modesti, M., Falkenberg, M., Wuite, G. J. & Peterman, E. J. G. Unraveling the structure of DNA during overstretching by using multicolor, single-molecule fluorescence imaging. Proc Natl Acad Sci U S A 106, 18231-18236, (2009).
W. H. Roos, R. Bruinsma G. J. L. Wuite. Physical Virology. Nature Physics 6(10):733-743 (2010).
R.T. Dame, M.C. Noom, G.J.L. Wuite. Bacterial chromatin organization by H-NS protein unraveled using a dual DNA assay. Nature 444:387-390 (2006)
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For detailed information, please visit my personal homepage.