Iannuzzi's Group

Biophysics

Fiber-top and ferrule-top sensors are a new generation of all-optical devices obtained by fabricating tiny mechanical pieces (MicroElectroMechanicalSystems, or MEMS) on the tip of an optical fiber or of a ferruled optical fibers. In principle, these sensors allow one to exert a calibrated pressure on cells or tissues and simultaneously collect light from or shine light to the sample exactly in the point where the pressure is applied. We are exploring whether this possibility can be used to combine indentation with optogenetics, spectroscopic techniques, and optical imaging techniques to shed new light in cell and tissue biology, with applications ranging from fundamental biophysics questions to the development of novel clinical instruments.